The receptor-binding site of the measles virus hemagglutinin protein itself constitutes a conserved neutralizing epitope.
نویسندگان
چکیده
Here, we provide direct evidence that the receptor-binding site of measles virus (MV) hemagglutinin protein itself forms an effective conserved neutralizing epitope (CNE). Several receptor-interacting residues constitute the CNE. Thus, viral escape from neutralization has to be associated with loss of receptor-binding activity. Since interactions with both the signaling lymphocyte activation molecule (SLAM) and nectin4 are critical for MV pathogenesis, its escape, which results from loss of receptor-binding activity, should not occur in nature.
منابع مشابه
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عنوان ژورنال:
- Journal of virology
دوره 87 6 شماره
صفحات -
تاریخ انتشار 2013